BAIT
SLC11A2
DCT1, DMT1, NRAMP2, OK/SW-cl.20
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
GO Process (22)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cadmium ion transmembrane transport [IDA]
- cation transmembrane transport [IGI]
- cellular iron ion homeostasis [TAS]
- cellular response to oxidative stress [IDA]
- cobalt ion transport [IDA]
- copper ion transmembrane transport [IDA]
- copper ion transport [IDA]
- detection of oxygen [IEP]
- ferrous iron import [IDA]
- ferrous iron transport [IDA]
- lead ion transport [IDA]
- manganese ion transmembrane transport [IDA]
- manganese ion transport [IDA]
- multicellular organismal iron ion homeostasis [IMP]
- nickel cation transmembrane transport [IDA]
- nickel cation transport [IDA]
- response to hypoxia [IEP]
- response to iron ion [IEP]
- transmembrane transport [TAS]
- vanadium ion transport [IDA]
- zinc ion transmembrane transport [IDA]
Gene Ontology Molecular Function- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal part of cell [IDA]
- cell surface [IDA]
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- early endosome [IDA]
- late endosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane [IDA]
- nucleus [IDA]
- paraferritin complex [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP, TAS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
- vacuole [IMP]
Homo sapiens
PREY
ATP2B4
ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
ATPase, Ca++ transporting, plasma membrane 4
GO Process (23)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion homeostasis [IC]
- calcium ion import across plasma membrane [IC]
- calcium ion transmembrane transport [IMP]
- cellular calcium ion homeostasis [IDA]
- cellular response to epinephrine stimulus [IDA]
- ion transmembrane transport [TAS]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [IDA]
- negative regulation of arginine catabolic process [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of cardiac muscle hypertrophy in response to stress [IMP]
- negative regulation of citrulline biosynthetic process [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of nitric-oxide synthase activity [IDA]
- negative regulation of peptidyl-cysteine S-nitrosylation [NAS]
- negative regulation of the force of heart contraction [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transmembrane transport [IC]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to hydrostatic pressure [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.975354488 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.975354488490349, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC11A2 ATP2B4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.6679 | BioGRID | 3808633 | |
| SLC11A2 ATP2B4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9774 | BioGRID | 3048282 |
Curated By
- BioGRID