An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration.

Balastik M, Ferraguti F, Pires-da Silva A, Lee TH, Alvarez-Bolado G, Lu KP, Gruss P

TRIM RING finger proteins have been shown to play an important role in cancerogenesis, in the pathogenesis of some human hereditary disorders, and in the defense against viral infection, but the function of the majority of TRIM proteins remains unknown. Here, we show that TRIM RING finger protein TRIM2, highly expressed in the nervous system, is an UbcH5a-dependent ubiquitin ligase. ... [more]

Proc. Natl. Acad. Sci. U.S.A. Aug. 19, 2008; 105(33);12016-21 [Pubmed: 18687884]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

TRIM2

Gene Ontology Biological Process

Gene Ontology Molecular Function

myosin binding [NAS]protein binding [IPI]ubiquitin protein ligase activity [IDA]ubiquitin-protein transferase activity [IDA]zinc ion binding [NAS]

Gene Ontology Cellular Component