BAIT
ABCA1
ABC-1, ABC1, CERP, HDLDT1, TGD
ATP-binding cassette, sub-family A (ABC1), member 1
GO Process (23)
GO Function (14)
GO Component (6)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA, IMP]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- endosomal transport [IDA]
- high-density lipoprotein particle assembly [IMP]
- interleukin-1 beta secretion [IMP]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- lysosome organization [IDA]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IDA, IMP]
- phospholipid homeostasis [IMP]
- platelet dense granule organization [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- regulation of Cdc42 protein signal transduction [IMP]
- response to laminar fluid shear stress [IEP]
- response to low-density lipoprotein particle [IEP]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
UGP2
UDPG, UDPGP, UDPGP2, UGP1, UGPP1, UGPP2, pHC379
UDP-glucose pyrophosphorylase 2
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.
Recent work identified ABCA1 as the major regulator of plasma HDL-cholesterol responsible for the removal of excess choline-phospholipids and cholesterol from peripheral cells and tissues. ABCA1 function may depend on the association with heteromeric proteins and to identify these candidates a human liver yeast two-hybrid library was screened with the carboxyterminal 144 amino acids of ABCA1. Beta2-syntrophin was found to ... [more]
Biochem. Biophys. Res. Commun. May. 03, 2002; 293(2);759-65 [Pubmed: 12054535]
Throughput
- Low Throughput
Curated By
- BioGRID