SNTB2
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ABCA1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA, IMP]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- endosomal transport [IDA]
- high-density lipoprotein particle assembly [IMP]
- interleukin-1 beta secretion [IMP]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- lysosome organization [IDA]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IDA, IMP]
- phospholipid homeostasis [IMP]
- platelet dense granule organization [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- regulation of Cdc42 protein signal transduction [IMP]
- response to laminar fluid shear stress [IEP]
- response to low-density lipoprotein particle [IEP]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.
Recent work identified ABCA1 as the major regulator of plasma HDL-cholesterol responsible for the removal of excess choline-phospholipids and cholesterol from peripheral cells and tissues. ABCA1 function may depend on the association with heteromeric proteins and to identify these candidates a human liver yeast two-hybrid library was screened with the carboxyterminal 144 amino acids of ABCA1. Beta2-syntrophin was found to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ABCA1 SNTB2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID