BAIT
PDGFA
PDGF-A, PDGF1
platelet-derived growth factor alpha polypeptide
GO Process (44)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton organization [ISS]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell activation [TAS]
- cell projection assembly [ISS]
- cell-cell signaling [TAS]
- embryonic lung development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hair follicle development [ISS]
- innate immune response [TAS]
- lung alveolus development [ISS]
- negative chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- regulation of DNA biosynthetic process [IDA]
- regulation of actin cytoskeleton organization [TAS]
- regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling [ISS]
- regulation of glomerular mesangial cell proliferation [IDA]
- regulation of peptidyl-tyrosine phosphorylation [ISS]
- regulation of smooth muscle cell migration [IDA]
- response to wounding [IDA]
- skin development [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
THSD4
ADAMTSL-6, ADAMTSL6, FVSY9334, PRO34005, UNQ9334
thrombospondin, type I, domain containing 4
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.751622283 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.751622283446764, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Curated By
- BioGRID