BAIT
POLE2
DPE2
polymerase (DNA directed), epsilon 2, accessory subunit
GO Process (13)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication [TAS]
- DNA replication initiation [TAS]
- DNA-dependent DNA replication [IBA]
- G1/S transition of mitotic cell cycle [TAS]
- error-prone translesion synthesis [IBA]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [TAS]
- nucleotide-excision repair, DNA gap filling [TAS]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
SAP18
2HOR0202, SAP18P, GIG38
Sin3A-associated protein, 18kDa
GO Process (5)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of nucleic acid-templated transcription [TAS]
- positive regulation of apoptotic process [IDA]
- regulation of alternative mRNA splicing, via spliceosome [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA.
DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase activity. To date, ... [more]
J. Biochem. Mar. 01, 2002; 131(3);307-11 [Pubmed: 11872158]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POLE2 SAP18 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID