EXOSC4
Gene Ontology Biological Process
- DNA deamination [IDA]
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, exonucleolytic [NAS]
- defense response to virus [IMP]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [TAS]
- gene expression [TAS]
- histone mRNA catabolic process [IMP]
- mRNA metabolic process [TAS]
- maturation of 5.8S rRNA [IMP]
- nuclear mRNA surveillance [IMP]
- nuclear-transcribed mRNA catabolic process [IMP]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- positive regulation of cell growth [IMP]
- rRNA processing [NAS]
Gene Ontology Molecular Function
EXOSC4
Gene Ontology Biological Process
- DNA deamination [IDA]
- RNA metabolic process [TAS]
- RNA phosphodiester bond hydrolysis, exonucleolytic [NAS]
- defense response to virus [IMP]
- exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [TAS]
- gene expression [TAS]
- histone mRNA catabolic process [IMP]
- mRNA metabolic process [TAS]
- maturation of 5.8S rRNA [IMP]
- nuclear mRNA surveillance [IMP]
- nuclear-transcribed mRNA catabolic process [IMP]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- positive regulation of cell growth [IMP]
- rRNA processing [NAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
The exosome is a complex of 3'-->5' exoribonucleases, which functions in a variety of cellular processes, all requiring the processing or degradation of RNA. Here we present a model for the assembly of the six human RNase PH-like exosome subunits into a hexameric ring structure. In part, this structure is on the basis of the evolutionarily related bacterial degradosome, the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| EXOSC4 EXOSC4 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.9498 | BioGRID | 2457189 |
Curated By
- BioGRID