WNT3
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [IMP]
- canonical Wnt signaling pathway involved in osteoblast differentiation [IMP]
- cell fate commitment [IBA]
- cell morphogenesis [IMP]
- cellular response to retinoic acid [ISS]
- limb bud formation [IMP]
- mammary gland epithelium development [IEP]
- neuron differentiation [IBA, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT3A
Gene Ontology Biological Process
- COP9 signalosome assembly [ISS]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [IDA]
- cell proliferation in forebrain [ISS]
- cellular response to retinoic acid [ISS]
- negative regulation of heart induction by canonical Wnt signaling pathway [IDA]
- negative regulation of neurogenesis [ISS]
- negative regulation of neuron projection development [ISS]
- neuron differentiation [IBA, ISS]
- palate development [IMP]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of catenin import into nucleus [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of dermatome development [IDA]
- positive regulation of mesodermal cell fate specification [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999986 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999985887007, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT3A WNT3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1193244 | |
| WNT3A WNT3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2216551 | |
| WNT3 WNT3A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3124695 |
Curated By
- BioGRID