GDNF
Gene Ontology Biological Process
- adult locomotory behavior [TAS]
- axon guidance [TAS]
- branching involved in ureteric bud morphogenesis [ISS]
- enteric nervous system development [ISS]
- mRNA stabilization [IDA]
- metanephros development [ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of neuron apoptotic process [IDA]
- nervous system development [TAS]
- neural crest cell migration [IDA]
- neuron projection development [IDA]
- peristalsis [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA]
- positive regulation of dopamine secretion [TAS]
- positive regulation of monooxygenase activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of ureteric bud formation [IDA]
- postganglionic parasympathetic nervous system development [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IDA]
- regulation of morphogenesis of a branching structure [ISS]
- signal transduction [TAS]
- sympathetic nervous system development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MKLN1
Gene Ontology Biological Process
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.990338095 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.9903380946753, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GDNF MKLN1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8237 | BioGRID | 1175962 |
Curated By
- BioGRID