BAIT
IL21
CVID11, IL-21, Za11
interleukin 21
GO Process (11)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cell maturation [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-gamma biosynthetic process [NAS]
- positive regulation of interleukin-17 production [IDA]
- positive regulation of tissue remodeling [IC]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACACB
ACC2, ACCB, HACC275
acetyl-CoA carboxylase beta
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [IDA]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [IDA]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Status: Pre-Publication Dataset
Quantitative Score
- 0.9707378 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.970737799556056, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Curated By
- BioGRID