LRPAP1
Gene Ontology Biological Process
- extracellular negative regulation of signal transduction [IDA]
- negative regulation of beta-amyloid clearance [IGI]
- negative regulation of protein binding [IDA]
- negative regulation of very-low-density lipoprotein particle clearance [IDA]
- protein folding [TAS]
- receptor-mediated endocytosis [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
LRP4
Gene Ontology Biological Process
- dendrite morphogenesis [ISS]
- extracellular matrix organization [TAS]
- kidney development [IDA]
- limb development [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of ossification [IMP]
- positive regulation of presynaptic membrane organization [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein heterotetramerization [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- synapse organization [ISS]
- synaptic growth at neuromuscular junction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999999952 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999999952340404, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LRPAP1 LRP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2222770 | |
| LRPAP1 LRP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3134361 |
Curated By
- BioGRID