PITX2
Gene Ontology Biological Process
- camera-type eye development [IMP]
- cardiac neural crest cell migration involved in outflow tract morphogenesis [ISS]
- cell proliferation involved in outflow tract morphogenesis [ISS]
- deltoid tuberosity development [IMP]
- determination of left/right symmetry [ISS]
- hair cell differentiation [IC]
- iris morphogenesis [IMP]
- left/right axis specification [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- odontogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prolactin secreting cell differentiation [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- somatotropin secreting cell differentiation [TAS]
- spleen development [ISS]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- ribonucleoprotein complex binding [IC]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- ribonucleoprotein complex binding [IC]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
AHCYL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.999992813 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.999992813240701, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PITX2 AHCYL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3652203 | |
| PITX2 AHCYL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9901 | BioGRID | 1184783 | |
| PITX2 AHCYL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9816 | BioGRID | 2244527 | |
| PITX2 AHCYL1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3098160 |
Curated By
- BioGRID