PPA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PNPT1
Gene Ontology Biological Process
- RNA catabolic process [IDA]
- RNA import into mitochondrion [IDA]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IDA]
- RNA polyadenylation [IDA]
- cellular response to interferon-beta [IDA]
- cellular response to oxidative stress [IDA]
- mRNA catabolic process [IDA]
- mitochondrial RNA 3'-end processing [IMP]
- mitochondrial RNA 5'-end processing [IMP]
- mitochondrial RNA catabolic process [IDA]
- mitochondrial mRNA catabolic process [IDA]
- mitochondrial mRNA polyadenylation [IMP]
- mitochondrion morphogenesis [ISS]
- mitotic cell cycle arrest [IDA]
- negative regulation of growth [IDA]
- nuclear polyadenylation-dependent mRNA catabolic process [IDA]
- positive regulation of mRNA catabolic process [IMP]
- positive regulation of miRNA catabolic process [IDA]
- positive regulation of mitochondrial RNA catabolic process [IDA]
- protein homooligomerization [IDA]
- protein homotrimerization [IDA]
- rRNA import into mitochondrion [IDA]
- regulation of cellular respiration [ISS]
- regulation of cellular senescence [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.765937113 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.765937112614708, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPA2 PNPT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7946 | BioGRID | 1184082 |
Curated By
- BioGRID