NUMBL
Gene Ontology Biological Process
- adherens junction organization [ISO]
- axonogenesis [ISO]
- cytokine-mediated signaling pathway [ISO, ISS]
- forebrain development [ISO]
- lateral ventricle development [ISO, ISS]
- nervous system development [ISO]
- neuroblast division in subventricular zone [ISO, ISS]
- neuroblast proliferation [ISO]
- positive regulation of dendrite morphogenesis [IMP]
- positive regulation of neurogenesis [ISO, ISS]
- protein metabolic process [ISO, ISS]
Gene Ontology Molecular Function
AUP1
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
The cytokines TNFalpha and IL-1beta induce inflammation through activation of transcription factors NF-kappaB. TAB2 is an adapter protein that facilitates TNFalpha and IL-1beta-mediated NF-kappaB activation. In this work, using yeast two-hybrid system TAB2 was identified to interact with NUMBL. The interaction was further confirmed in vitro and in vivo. PTB domain of NUMBL and C-terminal region are required for their ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID