BAIT
RPS6KB1
ribosomal protein S6 kinase, polypeptide 1
GO Process (43)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- TOR signaling [ISO]
- aging [IEP]
- cell migration [IEP]
- cellular response to growth factor stimulus [ISO, ISS]
- cellular response to hormone stimulus [IEP]
- germ cell development [ISO]
- long-term memory [IEP]
- negative regulation of apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of insulin receptor signaling pathway [IMP, ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of skeletal muscle tissue growth [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of translation [ISO]
- positive regulation of translational initiation [ISO]
- protein kinase B signaling [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of glucose import [IMP]
- response to amino acid [IEP]
- response to drug [IEP]
- response to electrical stimulus involved in regulation of muscle adaptation [IEP]
- response to ethanol [IEP]
- response to glucagon [IEP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to insulin [IEP, IMP]
- response to leucine [IEP]
- response to lipopolysaccharide [IEP]
- response to mechanical stimulus [IEP]
- response to nutrient [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IEP]
- response to testosterone [IEP]
- response to toxic substance [IEP]
- response to tumor necrosis factor [IMP]
- response to wounding [IEP]
- skeletal muscle atrophy [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RBX1
BA554C12.1, RNF75, ROC1, RP11-554C12.1
ring-box 1, E3 ubiquitin protein ligase
GO Process (9)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA, ISS]
- cellular response to hypoxia [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein neddylation [IDA]
- protein ubiquitination [IDA]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Cul2-RING ubiquitin ligase complex [IDA]
- Cul3-RING ubiquitin ligase complex [IDA]
- Cul4A-RING E3 ubiquitin ligase complex [IDA]
- Cul4B-RING E3 ubiquitin ligase complex [IDA]
- Cul5-RING ubiquitin ligase complex [IDA]
- Cul7-RING ubiquitin ligase complex [IDA]
- SCF ubiquitin ligase complex [IDA, ISS]
- cullin-RING ubiquitin ligase complex [IDA]
- cytosol [ISS, TAS]
- nucleoplasm [TAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1.
Ribosomal protein S6 kinase (S6K) is involved in the regulation of cell growth and cellular metabolism. The activation of S6K in response to diverse extracellular stimuli is mediated by multiple phosphorylations coordinated by the mTOR and PI3K signaling pathways. We have recently found that both forms of S6K are modified by ubiquitination. Following these findings, we demonstrate here for the ... [more]
Biochem. Biophys. Res. Commun. May. 02, 2008; 369(2);339-43 [Pubmed: 18279656]
Throughput
- Low Throughput
Curated By
- BioGRID