MADD
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- cell surface receptor signaling pathway [TAS]
- execution phase of apoptosis [IMP]
- positive regulation of Rab GTPase activity [IDA, IMP]
- regulation of Rab protein signal transduction [IDA]
- regulation of apoptotic process [IMP]
- regulation of cell cycle [IMP]
- regulation of extrinsic apoptotic signaling pathway [IDA]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIP4K2C
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BioPlex Network of Human Protein Interactions: Additional Unpublished AP-MS Results (Pre-Publication)
As part of an ongoing effort led by Steve Gygi, Wade Harper, and Ed Huttlin in the Department of Cell Biology at Harvard Medical School, we are systematically profiling the interactions among human proteins using affinity purification mass spectrometry. In this effort, HA-tagged bait proteins obtained from the human ORFeome collection (version 8.1; Marc Vidal) are expressed individually in human ... [more]
Quantitative Score
- 0.994907484 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT (unpublished interaction)
- BioPlex HCT HCT116 cells CompPASS score = 0.994907483766221, threshold = 0.362. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.362 threshold represents the top 2% of scores in HCT116.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MADD PIP4K2C | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3074815 |
Curated By
- BioGRID