Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.

Huang M, Lin Y, Wang L, You X, Wang S, Zhao J, Bai M, Li Z, Chen Y

Fat storage and mobilization in adipose tissue play a central role in energy metabolism and are directly linked to the development of obesity. Upon starvation, fat is mobilized from adipose tissue by lipolysis, a process by which triglycerides are hydrolyzed to free fatty acids to be used as an energy source in skeletal muscles and other tissues. However, how lipolysis ... [more]

Mol Metab Dec. 01, 2020; 47();101182 [Pubmed: 33549845]

Throughput

  • Low Throughput

Additional Notes

  • Proximity Ligation Assay

Curated By

  • BioGRID