BAIT

FBXO2

FBG1, FBX2, Fbs1, NFB42, OCP1
F-box protein 2
UPS Project
Homo sapiens
PREY

MMD

MMA, MMD1, PAQR11
monocyte to macrophage differentiation-associated
GO Process (0)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.

Huang M, Lin Y, Wang L, You X, Wang S, Zhao J, Bai M, Li Z, Chen Y

Fat storage and mobilization in adipose tissue play a central role in energy metabolism and are directly linked to the development of obesity. Upon starvation, fat is mobilized from adipose tissue by lipolysis, a process by which triglycerides are hydrolyzed to free fatty acids to be used as an energy source in skeletal muscles and other tissues. However, how lipolysis ... [more]

Mol Metab Dec. 01, 2020; 47();101182 [Pubmed: 33549845]

Throughput

  • Low Throughput

Additional Notes

  • Proximity Ligation Assay

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MMD FBXO2
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-

Curated By

  • BioGRID