PDE4D
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- adrenergic receptor signaling pathway [ISS]
- adrenergic receptor signaling pathway involved in positive regulation of heart rate [IC]
- cAMP catabolic process [IDA, IGI, IMP]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to epinephrine stimulus [IDA]
- establishment of endothelial barrier [ISS]
- negative regulation of heart contraction [ISS]
- negative regulation of peptidyl-serine phosphorylation [ISS]
- negative regulation of relaxation of cardiac muscle [ISS]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-2 production [IMP]
- positive regulation of interleukin-5 production [IMP]
- regulation of cardiac muscle cell contraction [ISS]
- regulation of cell communication by electrical coupling involved in cardiac conduction [IC]
- regulation of heart rate [ISS]
- regulation of receptor activity [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [ISS]
- regulation of ryanodine-sensitive calcium-release channel activity [ISS]
Gene Ontology Molecular Function
- 3',5'-cyclic-AMP phosphodiesterase activity [IDA, IGI]
- 3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]
- ATPase binding [IPI]
- beta-2 adrenergic receptor binding [ISS]
- cAMP binding [IDA]
- drug binding [IPI]
- enzyme binding [ISS]
- ion channel binding [IPI, ISS]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
MMD
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Adipose tissue lipolysis is regulated by PAQR11 via altering protein stability of phosphodiesterase 4D.
Fat storage and mobilization in adipose tissue play a central role in energy metabolism and are directly linked to the development of obesity. Upon starvation, fat is mobilized from adipose tissue by lipolysis, a process by which triglycerides are hydrolyzed to free fatty acids to be used as an energy source in skeletal muscles and other tissues. However, how lipolysis ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MMD PDE4D | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MMD PDE4D | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3304075 |
Curated By
- BioGRID