BAIT
FBXO32
Fbx32, MAFbx
F-box protein 32
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
APPL1
APPL, DIP13alpha
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
GO Process (8)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cell proliferation [IDA]
- insulin receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- regulation of establishment of protein localization to plasma membrane [IMP]
- regulation of glucose import [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.
Ubiquitination by serving as a major degradation signal of proteins, but also by controlling protein functioning and localization, plays critical roles in most key cellular processes. Here, we show that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. We identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene. FBXO32 ... [more]
Cell Death Differ Dec. 01, 2020; 28(6);1837-1848 [Pubmed: 33462405]
Throughput
- Low Throughput
Curated By
- BioGRID