BAIT

FBXO32

Fbx32, MAFbx
F-box protein 32
UPS Project
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

EHD4

PAST4, FKSG7
EH-domain containing 4
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.

Habel N, El-Hachem N, Soysouvanh F, Hadhiri-Bzioueche H, Giuliano S, Nguyen S, Horak P, Gay AS, Debayle D, Nottet N, Beranger G, Paillerets BB, Bertolotto C, Ballotti R

Ubiquitination by serving as a major degradation signal of proteins, but also by controlling protein functioning and localization, plays critical roles in most key cellular processes. Here, we show that MITF, the master transcription factor in melanocytes, controls ubiquitination in melanoma cells. We identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene. FBXO32 ... [more]

Cell Death Differ Dec. 01, 2020; 28(6);1837-1848 [Pubmed: 33462405]

Throughput

  • Low Throughput

Curated By

  • BioGRID