PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TERT
Gene Ontology Biological Process
- DNA strand elongation [IDA]
- age-dependent telomere shortening [IBA]
- mitochondrion organization [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of Wnt signaling pathway [IGI]
- replicative senescence [IMP]
- telomere formation via telomerase [IDA]
- telomere maintenance [TAS]
- telomere maintenance via telomerase [IMP, NAS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
- DNA binding [IDA]
- RNA-directed DNA polymerase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- tRNA binding [IDA]
- telomerase activity [IDA]
- telomeric DNA binding [TAS]
- telomeric RNA binding [IDA]
- telomeric template RNA reverse transcriptase activity [IDA, TAS]
- transcription coactivator binding [IPI]
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Telomerase is controlled by protein kinase Calpha in human breast cancer cells.
Telomerase, a specialized RNA-directed DNA polymerase that extends telomeres of eukaryotic chromosomes, is repressed in human somatic tissues and becomes activated during tumor progression in most human cancers. To date, little is known about how telomerase is activated and controlled in cancer, although activation is thought to be involved in cancer cell immortalization. Here, we report that human telomerase-associated protein ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID