BAIT
RCHY1
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
GO Process (5)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RBMX
HNRNPG, HNRPG, RBMXP1, RBMXRT, RNMX, hnRNP-G, RP11-1114A5.1
RNA binding motif protein, X-linked
GO Process (12)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- RNA splicing [TAS]
- cellular response to interleukin-1 [IDA]
- gene expression [TAS]
- mRNA splicing, via spliceosome [IC, TAS]
- membrane protein ectodomain proteolysis [IDA]
- negative regulation of mRNA splicing, via spliceosome [ISS]
- osteoblast differentiation [IDA]
- positive regulation of mRNA splicing, via spliceosome [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein homooligomerization [ISS]
- regulation of alternative mRNA splicing, via spliceosome [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.
The RING-finger protein Pirh2 is a p53 family-specific E3 ubiquitin ligase. Pirh2 also ubiquitinates several other important cellular factors and is involved in carcinogenesis. However, its functional role in other cellular processes is poorly understood. To address this question, we performed a proteomic search for novel interacting partners of Pirh2. Using the GST-pulldown approach combined with LC-MS/MS, we revealed 225 ... [more]
Cell Death Dis Dec. 05, 2020; 12(6);581 [Pubmed: 34091597]
Throughput
- Low Throughput
Curated By
- BioGRID