BAIT
RCHY1
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
GO Process (5)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP9X
DFFRX, FAF, FAM, MRX99, RP5-1172N10.4
ubiquitin specific peptidase 9, X-linked
GO Process (12)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- axon extension [IMP]
- female gamete generation [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- neuron migration [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.
The RING-finger protein Pirh2 is a p53 family-specific E3 ubiquitin ligase. Pirh2 also ubiquitinates several other important cellular factors and is involved in carcinogenesis. However, its functional role in other cellular processes is poorly understood. To address this question, we performed a proteomic search for novel interacting partners of Pirh2. Using the GST-pulldown approach combined with LC-MS/MS, we revealed 225 ... [more]
Cell Death Dis Dec. 05, 2020; 12(6);581 [Pubmed: 34091597]
Throughput
- Low Throughput
Curated By
- BioGRID