BAIT

NONO

NMT55, NRB54, P54, P54NRB, PPP1R114
non-POU domain containing, octamer-binding
Homo sapiens
PREY

MTHFD1

MTHFC, MTHFD
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.

Zhang F, Tang X, Fan S, Liu X, Sun J, Ju C, Liang Y, Liu R, Zhou R, Yu B, Zhang C, Zhang Z, Kang T, Huang G, Lv XB

BRAF inhibitors (BRAFi) that target BRAF V600E kinase, a driver mutation found in 50% of melanomas, show a significant antitumor response, but the common emergence of acquired resistance remains a challenge. Abnormal expression of RAF isoforms CRAF and ARAF reactivates pERK1/2, which plays crucial roles in the acquisition of resistance of melanoma cells. However, the mechanisms of dysregulation of RAF ... [more]

Oncogene Dec. 01, 2020; 40(24);4137-4150 [Pubmed: 34017080]

Throughput

  • High Throughput

Additional Notes

  • Source of NONO not clear

Curated By

  • BioGRID