BAIT
NONO
NMT55, NRB54, P54, P54NRB, PPP1R114
non-POU domain containing, octamer-binding
GO Process (4)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARF4
ARF2
ADP-ribosylation factor 4
GO Process (6)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors.
BRAF inhibitors (BRAFi) that target BRAF V600E kinase, a driver mutation found in 50% of melanomas, show a significant antitumor response, but the common emergence of acquired resistance remains a challenge. Abnormal expression of RAF isoforms CRAF and ARAF reactivates pERK1/2, which plays crucial roles in the acquisition of resistance of melanoma cells. However, the mechanisms of dysregulation of RAF ... [more]
Oncogene Dec. 01, 2020; 40(24);4137-4150 [Pubmed: 34017080]
Throughput
- High Throughput
Additional Notes
- Source of NONO not clear
Curated By
- BioGRID