SIX1
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- generation of neurons [ISS]
- inner ear development [ISS]
- inner ear morphogenesis [ISS]
- kidney development [ISS]
- mesonephric tubule formation [ISS]
- metanephric mesenchyme development [ISS]
- myoblast migration [ISS]
- negative regulation of neuron apoptotic process [ISS]
- organ induction [ISS]
- pattern specification process [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ureteric bud formation [ISS]
- protein localization to nucleus [IDA]
- regulation of branch elongation involved in ureteric bud branching [ISS]
- regulation of neuron differentiation [ISS]
- regulation of transcription, DNA-templated [ISS]
- skeletal muscle tissue development [ISS]
- thymus development [ISS]
- thyroid gland development [ISS]
- ureteric bud development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
USP8
Gene Ontology Biological Process
- cell proliferation [TAS]
- endosome organization [IMP]
- mitotic cytokinesis [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.
Prostate cancer (PC) is the second most common cancer with limited treatment option in males. Although the reactivation of embryonic signals in adult cells is one of the characteristics of cancer, the underlying protein degradation mechanism remains elusive. Here, we show that the molecular chaperone GRP75 is a key player in PC cells by maintaining the protein stability of SIX1, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID