BAIT
SIX1
BOS3, DFNA23, TIP39
SIX homeobox 1
GO Process (26)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- generation of neurons [ISS]
- inner ear development [ISS]
- inner ear morphogenesis [ISS]
- kidney development [ISS]
- mesonephric tubule formation [ISS]
- metanephric mesenchyme development [ISS]
- myoblast migration [ISS]
- negative regulation of neuron apoptotic process [ISS]
- organ induction [ISS]
- pattern specification process [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of ureteric bud formation [ISS]
- protein localization to nucleus [IDA]
- regulation of branch elongation involved in ureteric bud branching [ISS]
- regulation of neuron differentiation [ISS]
- regulation of transcription, DNA-templated [ISS]
- skeletal muscle tissue development [ISS]
- thymus development [ISS]
- thyroid gland development [ISS]
- ureteric bud development [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
TPM1
C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
tropomyosin 1 (alpha)
GO Process (17)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular component movement [TAS]
- cellular response to reactive oxygen species [IEP]
- cytoskeleton organization [TAS]
- muscle contraction [TAS]
- muscle filament sliding [ISS, TAS]
- negative regulation of cell migration [ISS]
- positive regulation of ATPase activity [ISS]
- positive regulation of cell adhesion [ISS]
- positive regulation of heart rate by epinephrine [ISS]
- positive regulation of stress fiber assembly [ISS]
- regulation of heart contraction [TAS]
- regulation of muscle contraction [TAS]
- ruffle organization [ISS]
- sarcomere organization [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.
Prostate cancer (PC) is the second most common cancer with limited treatment option in males. Although the reactivation of embryonic signals in adult cells is one of the characteristics of cancer, the underlying protein degradation mechanism remains elusive. Here, we show that the molecular chaperone GRP75 is a key player in PC cells by maintaining the protein stability of SIX1, ... [more]
Oncogene Dec. 01, 2020; 40(25);4291-4306 [Pubmed: 34079090]
Throughput
- Low Throughput
Curated By
- BioGRID