NGFR
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- circadian regulation of gene expression [ISS]
- glucose homeostasis [ISS]
- intracellular protein transport [ISS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of glucose import in response to insulin stimulus [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IRAK1
Gene Ontology Biological Process
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- activation of NF-kappaB-inducing kinase activity [IDA]
- innate immune response [TAS]
- interleukin-1-mediated signaling pathway [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, TAS]
- positive regulation of MAP kinase activity [IBA]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of transcription, DNA-templated [NAS]
- protein autophosphorylation [IDA, NAS]
- protein oligomerization [IMP]
- protein phosphorylation [TAS]
- protein ubiquitination [TAS]
- regulation of cytokine-mediated signaling pathway [IMP]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [IMP]
- signal transduction [NAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [IMP, TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [IBA, TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein serine/threonine kinase signaling pathway [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B.
The neurotrophin nerve growth factor (NGF) supports neuronal survival by activating the transcription factor nuclear factor-kappaB (NF-kappaB). We report here, for the first time, the identification of p75-associated kinase that mediates NGF-driven NF-kappaB activation. Using co-immunoprecipitation, we demonstrate an NGF-dependent association of interleukin 1 receptor-associated kinase (IRAK) with the p75 neurotrophin receptor in PC12 cells. Our results reveal that IRAK ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID