COPS6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PKP2
Gene Ontology Biological Process
- adherens junction maintenance [ISO]
- bundle of His cell to Purkinje myocyte communication [ISO]
- cardiac muscle cell action potential [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cell-cell signaling involved in cardiac conduction [ISO]
- desmosome assembly [ISO]
- gap junction assembly [ISO]
- heart development [IMP]
- intermediate filament bundle assembly [ISO]
- lipid homeostasis [ISO]
- maintenance of organ identity [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of tight junction assembly [ISO]
- single organismal cell-cell adhesion [IMP]
- ventricular cardiac muscle cell action potential [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Dysregulated protein degradative pathways are increasingly recognized as mediators of human disease. This mechanism may have particular relevance to desmosomal proteins that play critical structural roles in both tissue architecture and cell-cell communication, as destabilization/breakdown of the desmosomal proteome is a hallmark of genetic-based desmosomal-targeted diseases, such as the cardiac disease arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, no information exists ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| COPS6 PKP2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID