PAGR1
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIN1
Gene Ontology Biological Process
- calcium ion homeostasis [ISS]
- calcium ion transmembrane transport [IDA]
- cation transport [IDA]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IBA, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- propylene metabolic process [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [IDA]
- response to ethanol [IDA]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA]
- cell surface [ISS]
- dendrite [IDA]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- integral component of plasma membrane [IDA]
- neuron projection [ISS]
- plasma membrane [TAS]
- postsynaptic density [ISS]
- postsynaptic membrane [IBA, ISS]
- synapse [ISS]
- synaptic cleft [ISS]
- synaptic vesicle [ISS]
- terminal bouton [ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.
Activating signal cointegrator-2 (ASC-2), a coactivator of multiple nuclear receptors and transcription factors, belongs to a steady-state complex named ASCOM (for ASC-2 complex), which contains histone H3 lysine 4 (H3K4) methyltransferase MLL3 or its paralog MLL4. ASC-2 binds to many nuclear receptors in a ligand-dependent manner through its two LxxLL motifs. Here we show that the first LxxLL motif of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID