BAIT
CCNF
FBX1, FBXO1
cyclin F
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ARHGDIA
GDIA1, HEL-S-47e, NPHS8, RHOGDI, RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha
GO Process (10)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- cellular component movement [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell adhesion [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- semaphorin-plexin signaling pathway [ISS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.
Previously, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Hallmark features of these diseases include the build-up of insoluble protein aggregates as well as the mislocalization of proteins such as transactive response DNA binding protein 43 kDa (TDP-43). In recent years, the dysregulation of SFPQ (splicing factor ... [more]
Hum Mol Genet May. 31, 2021; 30(11);971-984 [Pubmed: 33729478]
Quantitative Score
- 1.573 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- Proximity Label-MS was carried out to identify high-confidence protein interactions with an abundance ratio that was >1.5 fold over control (Fold Abundance ratio over vector control reported)
Curated By
- BioGRID