BAIT

CCNF

FBX1, FBXO1
cyclin F
UPS Project
GO Process (3)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

LMO7

FBX20, FBXO20, LOMP, RP11-332E3.2
LIM domain 7
UPS Project
GO Process (1)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

Rayner SL, Cheng F, Hogan AL, Grima N, Yang S, Ke YD, Au CG, Morsch M, De Luca A, Davidson JM, Molloy MP, Shi B, Ittner LM, Blair I, Chung RS, Lee A

Previously, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Hallmark features of these diseases include the build-up of insoluble protein aggregates as well as the mislocalization of proteins such as transactive response DNA binding protein 43 kDa (TDP-43). In recent years, the dysregulation of SFPQ (splicing factor ... [more]

Hum Mol Genet May. 31, 2021; 30(11);971-984 [Pubmed: 33729478]

Quantitative Score

  • 100.0 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • Affinity Capture-MS was carried out to identify high-confidence protein interactions with an abundance ratio that was >1.5 fold over controls (Fold Abundance ratio over vector control reported)

Curated By

  • BioGRID