BAIT

BECN1P1

BECN1L1, BECN2
beclin 1, autophagy related, pseudogene 1
Autophagy Project
GO Process (3)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

CNR1

CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, RP1-23D17.1
cannabinoid receptor 1 (brain)
Human Papilloma Virus (HPV) Project
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B

The molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways remain incompletely understood. Here, we identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. However, Beclin 2, but not Beclin 1, functions in an additional lysosomal degradation pathway. Beclin 2 is required ... [more]

Cell Aug. 29, 2013; 154(5);1085-99 [Pubmed: 23954414]

Throughput

  • Low Throughput

Curated By

  • BioGRID