MAP1LC3B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CALCOCO1
Gene Ontology Biological Process
Gene Ontology Molecular Function- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- armadillo repeat domain binding [IPI]
- beta-catenin binding [IPI]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IMP, ISS]
- transcription cofactor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity label MS carried out to identfy high-confidence protein interactions
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP1LC3B CALCOCO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID