BAIT
SQSTM1
A170, OSIL, PDB3, ZIP3, p60, p62, p62B
sequestosome 1
GO Process (16)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- autophagy [IMP, TAS]
- endosomal transport [TAS]
- intracellular signal transduction [TAS]
- macroautophagy [ISS]
- negative regulation of apoptotic process [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- protein localization [TAS]
- protein phosphorylation [NAS]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of Ras protein signal transduction [NAS]
- response to stress [TAS]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MFF
C2orf33, GL004, AD030
mitochondrial fission factor
GO Process (13)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- mitochondrial fission [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrial fusion [IMP]
- mitochondrion morphogenesis [IMP]
- peroxisome fission [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]
Mol Cell Dec. 18, 2020; 81(6);1337-1354.e8 [Pubmed: 33545068]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity label MS carried out to identfy high-confidence protein interactions
Curated By
- BioGRID