BAIT
TOLLIP
IL-1RAcPIP
toll interacting protein
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BST2
CD317, TETHERIN
bone marrow stromal cell antigen 2
GO Process (19)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- defense response to virus [IDA]
- humoral immune response [TAS]
- innate immune response [IDA]
- multicellular organismal development [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of intracellular transport of viral material [IDA]
- negative regulation of plasmacytoid dendritic cell cytokine production [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of actin cytoskeleton organization [ISS]
- response to interferon-alpha [ISS]
- response to interferon-beta [ISS]
- response to interferon-gamma [ISS]
- response to virus [IDA]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]
Mol Cell Dec. 18, 2020; 81(6);1337-1354.e8 [Pubmed: 33545068]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity label MS carried out to identfy high-confidence protein interactions
Curated By
- BioGRID