BAIT
GRIN2A
EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, RP11-297M9.2
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GO Process (8)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DLGAP2
DAP-2, SAPAP2
discs, large (Drosophila) homolog-associated protein 2
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95. The second PDZ domain in PSD-95 binds to the seven-amino acid, COOH-terminal domain containing the terminal tSXV motif (where S is serine, X ... [more]
Science Sep. 22, 1995; 269(5231);1737-40 [Pubmed: 7569905]
Throughput
- Low Throughput
Curated By
- BioGRID