BAIT

CALCOCO2

NDP52
calcium binding and coiled-coil domain 2
Alzheimer's Disease Project
Autophagy Project
UPS Project
GO Process (2)
GO Function (2)
GO Component (5)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CSNK2A2

CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

Zellner S, Schifferer M, Behrends C

Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]

Mol Cell Dec. 18, 2020; 81(6);1337-1354.e8 [Pubmed: 33545068]

Throughput

  • High Throughput

Additional Notes

  • APEX2 proximity label MS carried out to identfy high-confidence protein interactions

Curated By

  • BioGRID