BAIT
CALCOCO2
NDP52
calcium binding and coiled-coil domain 2
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP6V1H
MSTP042, NBP1, SFD, SFDalpha, SFDbeta, VMA13, CGI-11
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
GO Process (13)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- ATP catabolic process [NAS]
- ATP hydrolysis coupled proton transport [NAS]
- cellular iron ion homeostasis [TAS]
- endocytosis [IDA]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- regulation of catalytic activity [NAS]
- regulation of defense response to virus by virus [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [NAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]
Mol Cell Dec. 18, 2020; 81(6);1337-1354.e8 [Pubmed: 33545068]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity label MS carried out to identfy high-confidence protein interactions
Curated By
- BioGRID