BAIT
TOLLIP
IL-1RAcPIP
toll interacting protein
GO Process (8)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADAM9
CORD9, MCMP, MDC9, Mltng
ADAM metallopeptidase domain 9
GO Process (25)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- PMA-inducible membrane protein ectodomain proteolysis [IDA, TAS]
- activation of MAPKK activity [IDA]
- cell adhesion [IMP]
- cell adhesion mediated by integrin [IMP]
- cell-cell adhesion mediated by integrin [IEP]
- cell-matrix adhesion [IMP]
- cellular response to lipopolysaccharide [IMP]
- collagen catabolic process [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- integrin-mediated signaling pathway [IC]
- keratinocyte differentiation [IEP]
- membrane protein ectodomain proteolysis [IDA, IMP]
- monocyte activation [IMP]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of macrophage fusion [IMP]
- positive regulation of membrane protein ectodomain proteolysis [ISS]
- positive regulation of protein secretion [IDA]
- response to calcium ion [IMP]
- response to glucocorticoid [ISS]
- response to hydrogen peroxide [IMP]
- response to manganese ion [IMP]
- response to tumor necrosis factor [IDA]
- transforming growth factor beta receptor signaling pathway [IMP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Autophagy deficiency in fed conditions leads to the formation of protein inclusions highlighting the contribution of this lysosomal delivery route to cellular proteostasis. Selective autophagy pathways exist that clear accumulated and aggregated ubiquitinated proteins. Receptors for this type of autophagy (aggrephagy) include p62, NBR1, TOLLIP, and OPTN, which possess LC3-interacting regions and ubiquitin-binding domains (UBDs), thus working as a bridge ... [more]
Mol Cell Dec. 18, 2020; 81(6);1337-1354.e8 [Pubmed: 33545068]
Throughput
- High Throughput
Additional Notes
- APEX2 proximity label MS carried out to identfy high-confidence protein interactions
Curated By
- BioGRID