BAIT

IL4I1

FIG1, LAAO, LAO, UNQ636/PRO1265
interleukin 4 induced 1
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

SLC25A3

PHC, PTP, OK/SW-cl.48
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

IL4I1 binds to TMPRSS13 and competes with SARS-Cov2 Spike

Gatineau J, Nidercorne C, Dupont A, Puiffe M-L, Cohen JL, Molinier-Frenkel V, Niedergang F, Castellano F

The secreted enzyme interleukin four-induced gene 1 (IL4I1) is involved in the negative control of the adaptive immune response. IL4I1 expression in human cancer is frequent and correlates with poor survival and resistance to immunotherapy. Nevertheless, its mechanism of action remains partially unknown. Here, we identified transmembrane serine protease 13 (TMPRSS13) as an immune cell-expressed surface protein that binds IL4I1. ... [more]

Status: Preliminary Report

Throughput

  • High Throughput

Curated By

  • BioGRID