CYLD
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RIPK1
Gene Ontology Biological Process
- T cell apoptotic process [IMP]
- amyloid fibril formation [ISO]
- apoptotic process [ISO]
- cellular protein catabolic process [ISO]
- cellular response to growth factor stimulus [IMP]
- cellular response to tumor necrosis factor [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- necroptotic process [IGI, ISO]
- necroptotic signaling pathway [IMP, ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- peptidyl-serine autophosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of JNK cascade [IMP, ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IGI, ISO]
- positive regulation of interleukin-8 production [ISO]
- positive regulation of macrophage differentiation [ISO]
- positive regulation of necroptotic process [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of programmed cell death [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transferase activity [IGI]
- positive regulation of tumor necrosis factor production [ISO]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [ISO]
- regulation of ATP:ADP antiporter activity [ISO]
- regulation of reactive oxygen species metabolic process [IMP]
- response to tumor necrosis factor [ISO]
- ripoptosome assembly [ISO]
- ripoptosome assembly involved in necroptotic process [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.
Spermatogenesis involves an early wave of germ cell apoptosis, which is required for maintaining the balance between germ cells and supporting Sertoli cells. However, the signaling mechanism regulating this apoptotic event is poorly defined. Here we show that genetic deficiency of Cyld, a recently identified deubiquitinating enzyme, attenuates the early wave of germ cell apoptosis and causes impaired spermatogenesis in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID