LRP1
Gene Ontology Biological Process
- aorta morphogenesis [IMP]
- apoptotic cell clearance [IMP]
- beta-amyloid clearance [IMP]
- cell proliferation [ISO]
- cholesterol metabolic process [IMP]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of smooth muscle cell migration [IMP]
- positive regulation of cholesterol efflux [IMP]
- positive regulation of lipid transport [IMP]
- positive regulation of protein transport [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cholesterol transport [IMP]
- regulation of phospholipase A2 activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TGFBR1
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI]
- artery morphogenesis [IMP]
- blastocyst development [IDA]
- cell motility [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- collagen fibril organization [IMP]
- embryo development [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- endothelial cell migration [IMP]
- epithelial to mesenchymal transition [ISO]
- germ cell migration [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- kidney development [IGI]
- lens development in camera-type eye [IMP]
- male gonad development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of endothelial cell differentiation [ISO]
- negative regulation of endothelial cell proliferation [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- neuron fate commitment [IMP]
- palate development [IGI, IMP]
- parathyroid gland development [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of filopodium assembly [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IGI, ISO]
- regulation of gene expression [IMP]
- regulation of protein binding [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cholesterol [IDA, ISO]
- response to estrogen [ISO]
- signal transduction [ISO]
- skeletal system development [IGI]
- skeletal system morphogenesis [IGI]
- thymus development [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPAR? Activation.
Arterial remodeling-a hallmark of many cardiovascular pathologies including pulmonary arterial hypertension (PAH)-is regulated by TGF?1 (transforming growth factor-?1)-TGF? receptors and the antagonistic, vasoprotective BMPR2 (bone morphogenetic protein receptor 2)-PPAR? (peroxisome proliferator-activated receptor-?) axis. However, it is unclear which factors drive detrimental TGF?1 pathways in the hypertensive pulmonary vasculature.We hypothesized that LRP1 (low-density lipoprotein receptor-related protein 1) expression is decreased in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID