KCNC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCE
Gene Ontology Biological Process
- TRAM-dependent toll-like receptor 4 signaling pathway [ISO, ISS]
- cellular response to ethanol [ISO]
- cellular response to hypoxia [ISO]
- intracellular signal transduction [IDA]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- locomotory exploration behavior [ISO]
- macrophage activation involved in immune response [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of mitochondrial calcium ion concentration [IMP]
- negative regulation of mitochondrial membrane potential [IMP]
- negative regulation of release of sequestered calcium ion into cytosol [IMP]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of actin filament polymerization [ISO, ISS]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of cellular glucuronidation [ISO]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of epithelial cell migration [ISO, ISS]
- positive regulation of fibroblast migration [ISO, ISS]
- positive regulation of insulin secretion [ISO]
- positive regulation of lipid catabolic process [ISO]
- positive regulation of mucus secretion [ISO]
- positive regulation of receptor activity [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of wound healing [ISO, ISS]
- protein phosphorylation [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- regulation of lipid metabolic process [ISO]
- regulation of peptidyl-tyrosine phosphorylation [ISO]
- release of sequestered calcium ion into cytosol [ISO]
- response to morphine [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
- 14-3-3 protein binding [ISO]
- SH3 domain binding [IPI]
- actin monomer binding [ISO, ISS]
- calcium-independent protein kinase C activity [ISO]
- enzyme activator activity [ISO]
- enzyme binding [ISO]
- ethanol binding [ISO]
- protein binding [IPI]
- protein kinase C activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [ISO]
- receptor activator activity [ISO]
- receptor binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PKC? associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner.
The voltage-gated potassium channel Kv3.4 is a crucial regulator of nociceptive signaling in the dorsal root ganglion (DRG) and the dorsal horn of the spinal cord. Moreover, Kv3.4 dysfunction has been linked to neuropathic pain. Although kinases and phosphatases can directly modulate Kv3.4 gating, the signaling mechanisms regulating the expression and stability of the Kv3.4 protein are generally unknown. We ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID