NCAM1
Gene Ontology Biological Process
- aging [IDA]
- calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules [TAS]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [ISO]
- cellular response to inorganic substance [IEP]
- cellular response to molecule of bacterial origin [IEP]
- homotypic cell-cell adhesion [ISO]
- learning or memory [IDA, IMP]
- multicellular organismal response to stress [IDA]
- negative regulation of cell death [IMP]
- neuron development [IDA]
- neuron projection development [ISO]
- organ regeneration [IEP]
- peripheral nervous system axon regeneration [IEP]
- positive regulation of calcium-mediated signaling [ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- regulation of exocyst assembly [ISO]
- regulation of sensory perception of pain [IMP]
- response to cocaine [IDA]
- response to fluoxetine [IDA]
- response to inorganic substance [IEP]
- response to lead ion [IDA]
- thalamus development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBB
Gene Ontology Biological Process
- adipose tissue development [ISO]
- energy homeostasis [ISO]
- fat pad development [ISO]
- female gonad development [ISO]
- female meiosis I [ISO]
- hypothalamus gonadotrophin-releasing hormone neuron development [ISO]
- male gonad development [ISO]
- male meiosis I [ISO]
- mitochondrion transport along microtubule [ISO]
- neuron projection morphogenesis [ISO]
- positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [ISO]
- regulation of mitochondrial membrane potential [ISO]
- regulation of neuron death [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- seminiferous tubule development [ISO]
- ubiquitin homeostasis [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NCAM is ubiquitylated, endocytosed and recycled in neurons.
The neural cell adhesion molecule NCAM plays an important role during neural development and in the adult brain. To study the intracellular trafficking of NCAM in neurons, two major isoforms, NCAM140 or NCAM180, were expressed in primary cortical neurons and in the rat B35 neuroblastoma cell line. NCAM was endocytosed and subsequently recycled to the plasma membrane, whereas only a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID