PLCG1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FLT1
Gene Ontology Biological Process
- angiogenesis [IMP, TAS]
- blood vessel morphogenesis [IMP]
- cell migration [IGI, IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- embryonic morphogenesis [IMP]
- monocyte chemotaxis [ISO]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of hematopoietic progenitor cell differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- protein autophosphorylation [ISO]
- response to hypoxia [IMP]
- sprouting angiogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IC, IMP, ISO]
- vascular endothelial growth factor receptor-1 signaling pathway [ISO]
- vascular endothelial growth factor signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein.
Elevated serum low-density lipoprotein (LDL) is a risk factor for atherosclerotic disorders. However, prominent atherosclerosis, which has been observed in LDL receptor (LDLR)-knockout mice, has diminished the significance of LDLR as a cause of atherosclerosis, while elaborate studies have focused on the receptors for denatured LDL. Here we report that native LDL (nLDL) activates vascular endothelial growth factor (VEGF) receptor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID