BAIT
SKP2
FBL1, FBXL1, FLB1, p45
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
GO Process (4)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MMP9
CLG4B, GELB, MANDP2, MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
GO Process (9)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- collagen catabolic process [TAS]
- endodermal cell differentiation [IEP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- macrophage differentiation [TAS]
- negative regulation of cation channel activity [IDA]
- positive regulation of keratinocyte migration [IMP]
- positive regulation of receptor binding [IDA]
- proteolysis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis.
Emerging evidence has shown that SKP1-cullin-1-F-box-protein (SCF) E3 ligases contribute to the pathogenesis of different cancers by mediating the ubiquitination and degradation of tumor suppressors. However, the functions of SCF E3 ligases in the pathogenesis of colorectal cancer (CRC) remain obscure.The cancerous and adjacent noncancerous tissues from CRC patients were collected, and protein levels were analyzed. Lentiviral short hairpin RNA ... [more]
Cancer Res Treat Jun. 29, 2021; (); [Pubmed: 34237211]
Throughput
- Low Throughput
Curated By
- BioGRID