FZD7
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA, IMP]
- cellular response to retinoic acid [ISS]
- mesenchymal to epithelial transition [IMP]
- negative regulation of cell-substrate adhesion [IMP]
- negative regulation of ectodermal cell fate specification [IMP]
- neuron differentiation [ISS]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- positive regulation of JNK cascade [IC]
- positive regulation of epithelial cell proliferation involved in wound healing [IMP]
- positive regulation of phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of catenin import into nucleus [IMP]
- regulation of transcription, DNA-templated [IMP]
- stem cell maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNAI3
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- cell division [IDA]
- negative regulation of adenylate cyclase activity [TAS]
- platelet activation [TAS]
- synaptic transmission [TAS]
- transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.
Wnt signaling is essential for tissue homeostasis and its dysregulation causes cancer. Wnt ligands trigger signaling by activating Frizzled receptors (FZDRs), which belong to the G-protein coupled receptor superfamily. However, the mechanisms of G protein activation in Wnt signaling remain controversial. In this study, we demonstrate that FZDRs activate G proteins and trigger non-canonical Wnt signaling via the Dishevelled-binding protein, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID