CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- brain development [ISS, NAS]
- cell proliferation [TAS]
- ephrin receptor signaling pathway [ISS]
- ionotropic glutamate receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- neuron cell-cell adhesion [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neuron projection development [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of neuron differentiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- contractile fiber [ISS]
- cytoplasm [ISS]
- cytosol [TAS]
- dendrite [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- neuromuscular junction [ISS]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [ISS]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
AMPH
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction.
Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer's disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I mediates both tau phosphorylation and synaptic dysfunction in AD. Amphiphysin I is cleaved by a cysteine proteinase asparagine endopeptidase (AEP) at N278 in the brains of AD patients. The amount of AEP-generated ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AMPH CDK5R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AMPH CDK5R1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID